Open Access Open Access  Restricted Access Subscription or Fee Access

Are physicians fully aware of the potential transgenerational and multigenerational effects of a large opioid misuse in the population?

Maurizio Coppola, MD, Raffaella Mondola, MD

Abstract


-

Full Text:

PDF

References


Albrizio M, Guaricci AC, Calamita G, et al.: Expression and immunolocalization of the mu-opioid receptor in human sperm cells. Fertil Steril. 2006; 86: 1776-1779.

Agirregoitia E, Peralta L, Mendoza R, et al.: Expression and localization of opioid receptors during the maturation of human oocytes. Reprod Biomed Online. 2012; 24: 550-557.

Nielsen DA, Yuferov V, Hamon S, et al.: Increased OPRM1 DNA methylation in lymphocytes of methadone-maintained former heroin addicts. Neuropsychopharmacology. 2009; 34: 867-873.

Knothe C, Doehring A, Ultsch A, et al.: Methadone induces hypermethylation of human DNA. Epigenomics. 2016; 8: 167-179.

Yohn NL, Bartolomei MS, Blendy JA: Multigenerational and transgenerational inheritance of drug exposure: The effects of alcohol, opiates, cocaine, marijuana, and nicotine. Prog Biophys Mol Biol. 2015; 118: 21-33.




DOI: http://dx.doi.org/10.5055/jom.2018.0454

Refbacks

  • There are currently no refbacks.
This site uses cookies to maintain session information critical to the user's experience and environment on this system. Click "Accept Cookies" to continue.
For more details please visit our privacy statement at: Privacy & GDPR