Role of gabapentin in postoperative pain

Alparslan Turan, MD





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Fishman S, Borsook D: Opioids in pain management. In Benzon H, Raja S, Molloy RE, et al. (Eds.): Essentials of Pain Medicine and Regional Anesthesia. New York: Churchill Livingstone, 1999: 51-54.

Woolf CJ, Salter MW: Neuronal plasticity: Increasing the gain in pain. Science 2000; 288: 1765-1769.

Scholz J, Woolf CJ: Can we conquer pain? Nat Neurosci. 2002; 5: 1062-1067.

Dahl JB, Mathiesen O, Moiniche S: Protective premedication: An option with gabapentin and related drugs? A review of gabapentin and pregabalin in the treatment of post-operative pain. Acta Anaesthesiol Scand. 2004; 48: 1130-1136.

Rosner H, Rubin L, Kestenbaum A: Gabapentin adjunctive therapy in neuropathic pain states. Clin J Pain. 1996; 12: 56-58.

Backonja M, Beydoun A, Edwards KR, et al.: Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: A randomized controlled trial. JAMA. 1998; 280: 1831-1836.

Rowbotham M, Harden N, Stacey B, et al.: Gabapentin for the treatment of postherpetic neuralgia: A randomized controlled trial. JAMA. 1998; 280: 1837-1842.

Mellick GA, Mellick LB: Reflex sympathetic dystrophy treated with gabapentin. Arch Phys Med Rehabil. 1997; 78: 98-105.

Mao J, Chen LL: Gabapentin in pain management. Anesth Analg. 2000; 91: 680-687.

Turan A, Karamanlioglu B, Memis D, et al.: The analgesic effects of gabapentin after total abdominal hysterectomy. Anesth Analg. 2004; 98: 1370-1373.

Dirks J, Fredensborg BB, Christensen D, et al.: A randomized study of the effects of single-dose gabapentin versus placebo on postoperative pain and morphine consumption after mastectomy. Anesthesiology. 2002; 97: 560-564.

Turan A, Memis D, Karamanlioglu B, et al.: The analgesic effects of gabapentin in monitored anesthesia care for ear-nosethroat surgery. Anesth Analg. 2004; 99: 375-378.

Turan A, Karamanlioglu B, Memis D, et al.: Analgesic effects of gabapentin after spinal surgery. Anesthesiology. 2004; 100: 935-938.

Shimoyama M, Shimoyama N, Hori Y: Gabapentin affects glutamatergic excitatory neurotransmission in the rat dorsal horn. Pain. 2000; 85: 405-414.

Yoon MH, Choi JI, Jeong SW: Spinal gabapentin and antinociception: Mechanisms of action. J Korean Med Sci. 2003; 18: 255-261.

Partridge BJ, Chaplan SR, Sakamoto E, et al.: Characterization of the effects of gabapentin and 3-isobutyl-gammaaminobutyric acid on substance P-induced thermal hyperalgesia. Anesthesiology. 1998; 88: 196-205.

Singh L, Field MJ, Ferris P, et al.: The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed by D-serine. Psychopharmacology (Berl). 1996; 127: 1-9.

Suarez LM, Suarez F, Del Olmo N, et al.: Presynaptic NMDA autoreceptors facilitate axon excitability: A new molecular target for the anticonvulsant gabapentin. Eur J Neurosci. 2005; 21: 197-209.

Taylor CP, Gee NS, Su TZ, et al.: A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res. 1998; 29: 233-249.

Maneuf YP, Gonzalez MI, Sutton KS, et al.: Cellular and molecular action of the putative GABA-mimetic, gabapentin. Cell Mol Life Sci. 2003; 60: 742-750.

Shimoyama M, Shimoyama N, Inturrisi CE, et al.: Gabapentin enhances the antinociceptive effects of spinal morphine in the rat tail-flick test. Pain. 1997; 72: 375-382.

Smiley MM, Lu Y, Vera-Portocarrero LP, et al.: Intrathecal gabapentin enhances the analgesic effects of subtherapeutic dose morphine in a rat experimental pancreatitis model. Anesthesiology. 2004; 101: 759-765.

Gilron I, Orr E, Tu D, et al.: A placebo controlled randomized clinical trial of perioperative administration of gabapentin, rofecoxib and their combination for spontaneous and movement evoked pain after abdominal hysterectomy. Pain. 2005; 113: 191-200.

Gilron I, Bailey JM, Tu D, et al.: Morphine, gabapentin, or their combination for neuropathic pain. N Engl J Med. 2005; 352: 1324-1334.



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