Self-reports of prescription opioid abuse and diversion among recreational opioid users in a Canadian and a United States city

Beatrice Setnik, PhD; Carl L. Roland, PharmD, MS; Veeraindar Goli, MD; Glenn C. Pixton, MS; Naama Levy-Cooperman, PhD; Ira Smith, MD; Lynn Webster, MD

doi:10.5055/jom.2015.0299

Authors

Beatrice Setnik, PhD
Carl L. Roland, PharmD, MS
Veeraindar Goli, MD
Glenn C. Pixton, MS
Naama Levy-Cooperman, PhD
Ira Smith, MD
Lynn Webster, MD

DOI:

https://doi.org/10.5055/jom.2015.0299

Keywords:

abuse, diversion, opioids, prescription opioids, questionnaire, recreational use

Abstract

Objective: To explore behaviors related to prescription opioid abuse and diversion in individuals who self-reported past recreational (nonmedical) opioid use.

Design: A questionnaire was developed and included in two abuse potential clinical studies conducted in Canada (Toronto, ON, August 2010 to January, 2011) and the United States (Salt Lake City, UT, February-May 2011).

Participants: Recreational opioid users.

Main outcome measure(s): Self-reported behaviors related to prescription opioid abuse and diversion.

Results: The questionnaire was completed by 174 participants in the Canadian study and 80 participants in the US study. Most participants reported that they used prescription opioids for nonmedical purposes a few times a month. Most had taken their first prescription opioid between the ages of 12 and 24 years and the two most common reasons were to treat pain or to feel high/stoned. When asked about specific opioids taken for nonmedical purposes in the past year, oxycodone, acetaminophen with codeine, and morphine were commonly used by both cohorts, whereas hydrocodone use was substantially greater in the US cohort versus the Canadian cohort. Participants reported various tampering methods and routes of administration, with swallowed whole, crushed and snorted, and chewed/crushed and swallowed as the most prevalent. Most participants indicated taking other drugs with prescription opioids to get high, most commonly marijuana and alcohol. The most common sources for obtaining prescription opioids were family/friends.

Conclusions: Two cohorts of recreational opioid users from Canada and the United States reported similar experiences with various prescription opioids and indicated a predominance of diversion from family/friends.

Author Biographies

Beatrice Setnik, PhD

Senior Director, Pfizer Inc, Durham, North Carolina

Carl L. Roland, PharmD, MS

Senior Director, Pfizer Inc, Durham, North Carolina

Veeraindar Goli, MD

Vice President, Clinical Disease Area Expert-Pain, Pfizer Inc, Durham, North Carolina; Professor Emeritus, Duke University Medical Center, Durham, North Carolina

Glenn C. Pixton, MS

Director, Statistics, Pfizer Inc, Durham, North Carolina

Naama Levy-Cooperman, PhD

INC Research, Toronto, Ontario, Canada

Ira Smith, MD

INC Research, Toronto, Ontario, Canada

Lynn Webster, MD

Medical Director, CRILifetree, Salt Lake City, Utah.

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