Open Access Open Access  Restricted Access Subscription or Fee Access

A case report of sweating caused by hydromorphone

Lauren E. Bode, PharmD, BCPS


Thermoregulatory control of shivering and sweating is a complex process that can be affected by centrally acting medications. Opioids, in particular fentanyl and methadone, have been associated with sweating, but it remains a relatively rare occurrence in clinical practice. Under-recognition of this medication side-effect may lead to patient discomfort as well as a potentially unnecessary work-up to determine the etiology of the sweating. Here, we discuss severe sweating caused by hydromorphone that resolved upon the medication's discontinuation.


opioid analgesics, sweating, thermoregulation

Full Text:



Cheshire WP, Fealey RD: Drug-induced hyperhidrosis and hypohidrosis: Incidence, prevention and management. Drug Saf. 2008; 31(2): 109-126.

Vinit J, Devilliers H, Audia S, et al.: [Excessive sweating related to hydromorphone]. Rev Med Interne. 2009; 30(2): 190-191.

Yaffe GJ, Strelinger RW, Parwatikar S: Physical symptom complaints of patients on methadone maintenance. Proc Natl Conf Methadone Treat. 1973; 1: 507-514.

Shah S: Resolution of sweating after switching from transdermal fentanyl to oral morphine sulphate. Palliat Med. 2006; 20(3): 222.

Sayyid SS, Jabbour DG, Baraka AS: Hypothermia and excessive sweating following intrathecal morphine in a parturient undergoing cesarean delivery. Reg Anesth Pain Med. 2003; 28(2): 140-143.

Ikeda T, Kurz A, Sessler DI, et al.: The effect of opioids on thermoregulatory responses in humans and the special anti-shivering action of meperidine. Ann N Y Acad Sci. 1997; 813: 792-798.

Cagnacci A, Melis GB, Soldani R, et al.: Regulation of body temperature in postmenopausal women: Interactions between bromocriptine and the endogenous opioid system. Life Sci. 1989; 44(19): 1395-1402.



  • There are currently no refbacks.