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Impact of non-benzodiazepine sleep hypnotics on opioid overdose risk

Van Nguyen, PharmD, Christopher M. Herndon, PharmD, BCACP

Abstract


Increasing concerns regarding concomitant use of benzodiazepines with opioids have been addressed by FDA drug safety communications and are increasingly recognized amongst prescribers. However, non-benzodiazepine sleep hypnotics continue to be prescribed with opioids.


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References


Cho J, Spence MM, Niu F, et al.: Risk of Overdose with Exposure to Prescription Opioids, Benzodiazepines, and Nonbenzodiazepine Sedative-Hypnotics in Adults: A Retrospective Cohort Study. J Gen Intern Med. 2020; 35: 696-703.

Turner BJ, Liang Y: Drug overdose in a retrospective cohort with non-cancer pain treated with opioids, antidepressants, and/or sedative-hypnotics: Interactions with mental health disorders. J Gen Intern Med. 2015; 30: 1081-1096.

Schifano F, Chiappini S, Corkery JM, et al.: An Insight into Z-Drug Abuse and Dependence: An Examination of Reports to the European Medicines Agency Database of Suspected Adverse Drug Reactions. Int J Neuropsychopharmacol. 2019; 22: 270-277.




DOI: https://doi.org/10.5055/jom.2020.0605

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