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Targin®: An effective opiate analgesia with minimal gastrointestinal side effects—An observational study

Scott Jones, Maiko Smith, Jeremy Rossaak, MBBCh, FRACS, PhD


Objective: To examine the role of Targin® (oral oxycodone:naloxone combination) in the perioperative setting.

Design: A single center prospective observational pilot study at a regional hospital.

Setting: Thirty-eight eligible patients undergoing major general surgical operations were recruited. Thirty-two patients completed the study.

Interventions: Participants were given Targin twice daily from day 2 postoperatively with twice daily measures of pain scores, gut function, and mobility.

Main outcome measures: The primary end points were analgesic efficacy and the rate of ileus. Secondary end points were gastrointestinal (GI) recovery and the need for opioid requirement on discharge, at 1 week and 1 month.

Results: Average pain score over 5 days at rest was one and on movement was four out of 10. All patients mobilized to a chair by day 3. Twenty-six participants (81.3 percent) experienced nausea at some point during the study, and four participants (12.5 percent) were diagnosed with a post-operative ileus (POI). There was no serious adverse event reported. Only two patients were on opioids at 1-month discharge. This was due to them having Orthopaedic surgery not related to this study.

Conclusions: Targin appears to provide effective analgesia when used responsibly in elective post-operative GI surgical patients, with a low rate of POI and long-term opiate use.


oxycodone, naloxone, post-operative ileus

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