Rethinking methadone for the management of chronic pain

Gary M. Reisfield, MD; Paul A. Sloan, MD

doi:10.5055/jom.2012.0126

Authors

Gary M. Reisfield, MD
Paul A. Sloan, MD

DOI:

https://doi.org/10.5055/jom.2012.0126

Keywords:

methadone, chronic pain, pain management

Author Biographies

Gary M. Reisfield, MD

Assistant Professor and Director, Pain Management Services, Division of Addiction Medicine, Department of Psychiatry, University of Florida College of Medicine, Gainesville, Florida

Paul A. Sloan, MD

Professor and Vice Chair for Research, Department of Anesthesiology, University of Kentucky, Lexington, Kentucky

References

Sloan PA, Babul N. Extended-release opioids for the management of chronic non-malignant pain. Expert Opinion Drug Deliv. 2006; 4:463-464.

Centers for Disease Control and Prevention (CDC). Vital signs: risk for overdose from methadone used for pain relief–United States, 1999-2010. MMWR Morb Mortal Wkly Rep. 2012 Jul 6;61(26):493-497.

Manchikanti L, Atluri S, Trescot AM, Giordano J. Monitoring opioid adherence in chronic pain patients: tools, techniques, and utility. Pain Physician. 2008;11:S155-S180.

Kuehn BM. Methadone overdose deaths rise with increased prescribing for pain. JAMA. 2012;308:749-750.

Kapur BM, Hutson JR, Chibber T, Luk A, Selby P. Methadone: a review of drug-drug and pathophysiological interactions. Crit Rev Clin Lab Sci. 2011;48:171-195.

Food and Drug Administration. Methadone package insert http://www.fda.gov/downloads/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/UCM142842.pdf. Accessed September 18, 2012.

Krantz MJ, Martin J, Stimmel B, Mehta D, Haigney MC. QTc interval screening in methadone treatment. Ann Intern Med. 2009;150:387-395.