Characteristics of prescribers whose patients shop for opioids: Results from a cohort study

Authors

  • M. Soledad Cepeda, MD, PhD
  • Daniel Fife, MD
  • Jesse A. Berlin, ScD
  • Gregory Mastrogiovanni, BS
  • Yingli Yuan, PhD

DOI:

https://doi.org/10.5055/jom.2012.0128

Keywords:

opioids, opioid shopping, abuse, diversion, prescribers

Abstract

Background: Little is known about the prevalence of opioid shoppers in clinical practices and the relation between prescriber characteristics and the risk of having opioid shoppers.

Objective: Describe the prevalence of opioid shoppers in prescribers’ practices. Assess the relation between prescribers’ characteristics and patient opioid shopping behavior.

Design: Retrospective cohort study using a large US retail prescription database. Patients, Participants: Patients with 1 opioid dispensing were followed 18 months. These patients’ prescribers are the focus of the study.

Main Outcome Measures: A patient was a “shopper” if he or she had opioid prescriptions written by 1 prescriber with 1 day of overlap filled at 3 pharmacies and a “heavy shopper” if he or she had 5 shopping episodes. The proportions of shoppers by prescriber and the proportion of prescribers with 1 shopper or heavy shopper were calculated.

Results: Among 858,290 opioid prescribers, most (87 percent) had no shoppers and 98 percent had no heavy shoppers. Prescribers who were aged 70-79 years, male, or who prescribed schedule II opioids had an increased likelihood of having shoppers. As the number of patients for whom a prescriber prescribed opioids increased, the proportion of shoppers also increased. Prescribers with 66 or more patients receiving opioids, who represented 25 percent of prescribers, prescribed for 82 percent of all shoppers.

Conclusion: The great majority of opioid prescribers appear to have no shoppers in their practice. Any educational program will be more cost effective if targeted to prescribers of schedule II opioids with a large volume of patients requiring opioids.

Author Biographies

M. Soledad Cepeda, MD, PhD

Janssen Pharmaceutical Research & Development, LLC, Titusville, New Jersey

Daniel Fife, MD

Janssen Pharmaceutical Research & Development, LLC, Titusville, New Jersey

Jesse A. Berlin, ScD

Janssen Pharmaceutical Research & Development, LLC, Titusville, New Jersey

Gregory Mastrogiovanni, BS

IMS Health, Collegeville, Pennsylvania

Yingli Yuan, PhD

IMS Health, Collegeville, Pennsylvania

References

US Department of Health and Human Services: Results from the 2009 National Survey on Drug Use and Health, 2011. Available at http://oas.samhsa.gov/NSDUH/2k9NSDUH/2k9Results.htm#2.16. Accessed July 10, 2012.

Hall AJ, Logan JE, Toblin RL, et al.: Patterns of abuse among unintentional pharmaceutical overdose fatalities. JAMA. 2008; 300(22): 2613-2620.

Paulozzi LJ, Budnitz DS, Xi Y: Increasing deaths from opioid analgesics in the United States. Pharmacoepidemiol Drug Saf. 2006; 15(9): 618-627.

Pradel V, Frauger E, Thirion X, et al.: Impact of a prescription monitoring program on doctor-shopping for high dosage buprenorphine. Pharmacoepidemiol Drug Saf. 2009; 18(1): 36-43.

Cepeda MS, Fife D, Chow W, et al.: Assessing opioid shopping behavior: A large cohort study from a medication dispensing database. Drug Saf. 2012; 35(4): 325-334.

Cepeda MS, Fife D, Chow W, et al.: Opioid shopping behavior: How often, how soon, which drugs, and what payment method. J Clin Pharmacol. 2012 (in press).

Published

09/01/2012

How to Cite

Cepeda, MD, PhD, M. S., D. Fife, MD, J. A. Berlin, ScD, G. Mastrogiovanni, BS, and Y. Yuan, PhD. “Characteristics of Prescribers Whose Patients Shop for Opioids: Results from a Cohort Study”. Journal of Opioid Management, vol. 8, no. 5, Sept. 2012, pp. 285-91, doi:10.5055/jom.2012.0128.