Depressive symptoms in community-dwelling older adults receiving opioid therapy for chronic pain

Authors

  • Robert Lavin, MD
  • Juyoung Park, PhD

DOI:

https://doi.org/10.5055/jom.2011.0072

Keywords:

older adults, depression, chronic pain, opioids

Abstract

Objective: The purpose of the study was to identify factors associated with depressive symptoms in community-dwelling older adults receiving prescription opioids for chronic pain.
Design: This was a cross-sectional research design. A survey was used to gather demographic information, pain severity, health status, and factors associated with depressive symptoms.
Setting: Eleven outpatient clinics affiliated with the Baltimore Veterans Affairs Medical Center and the University of Maryland Medical System were included.
Participants: One hundred sixty-three older adults receiving opioid medications for chronic pain were recruited.
Outcome measures: Depressive symptoms were assessed via the Center for Epidemiologic Studies Depression Scale-10 (CESD-10).
Results: Univariate, bivariate, and ordinary least square (OLS) regression analyses were conducted to identify frequencies and to address the research questions. Nearly 40 percent of the elderly opioid therapy patients had depressive symptoms on the CESD-10. Bivariate analysis revealed that higher levels of pain severity were related to higher levels of depressive symptoms. OLS regression analysis revealed four risk factors significantly associated with higher depressive symptoms: higher pain severity, lower levels of functional status, lower levels of spirituality, and lower levels of social support. Age, gender, living alone, and perception of health status were not significantly associated with depressive symptoms.
Conclusions: Depression is an underdiagnosed, treatable pain comorbidity that should be evaluated in older patients receiving opioid therapy. Undertreated depression in chronic pain patients receiving opioid medications may explain suboptimal improvement in pain and functional status despite increasing opioid dosage.

Author Biography

Juyoung Park, PhD

Assistant Professor, School of Social Work, Florida Atlantic University, Boca Raton, Florida.

References

Arnow BA, Blaisey CM, Lee J, et al.: Relationships among depression, chronic pain, chronic disabling pain, and medical costs. Psychiatr Serv. 2009; 60: 344-350.

Blazer DG, Hybels CF, Pieper CF: The association of depression and mortality in elderly persons: A case for multiple, independent pathways. J Gerontol A Biol Sci Med Sci. 2001; 56: M505-M509.

Sawyer P, Bodner E, Ritchie C, et al.: Pain and pain medication use in community-dwelling older adults. Am J Geriatr Pharmacother. 2006; 4: 316-324.

Bair M, Robinson R, Katon W, et al.: Depression and pain comorbidity. Arch Intern Med. 2003; 163: 2433-2445.

Dersh J, Gatchel RJ, Polatin P: Chronic spinal disorders and psychopathology: Research findings and theoretical considerations. Spine J. 2001; 1(2): 88-94.

Epker J, Block AR: Presurgical psychological screening in back pain patients: A review. Clin J Pain. 2001; 17: 200-205.

Gatchel JP, Garofalo EE, Holt C: Major psychological disorders in acute and chronic TMD: An initial examination. J Am Dent Assoc. 1996; 127: 1365-1370.

Manchikanti L, Giordano J, Boswell MV, et al.: Psychological factors as predictors of opioid abuse and illicit drug use in chronic pain patients. J Opioid Manag. 2007; 3: 89-100.

Sullivan MD, Von Korf M, Banta-Green C, et al.: Problems and concerns of patients receiving chronic opioid therapy for chronic noncancer pain. Pain. 2010; 149: 345-353.

Turk DC, Okifuji A: What factors affect physicians’ decisions to prescribe opioids for chronic noncancer pain patients? Clin J Pain. 1997; 13: 330-336.

Fillingim RB, Doleys DM, Edwards RR, et al.: Clinical characteristics of chronic back pain as a foundation of gender and oral opioid use. Spine. 2003; 28(2): 143-150.

Breckenridge J, Clark JD: Patient characteristics associated with opioid versus nonsteroidal anti-inflammatory drug management of chronic low back pain. J Pain. 2003; 4: 344-350.

American Geriatrics Society Panel on Persistent Pain in Older Persons: The management of persistent pain in older persons. J Am Geriatr Soc. 2002; 50 (Suppl): S205-S224.

Gianni W, Ceci M, Bustacchini S, et al.: Opioids for the treatment of chronic non-cancer pain in older people. Drug Aging. 2009; 26(S1): 63-73.

Barry LC, Gill TM, Kerns RD, et al.: Identification of painreduction strategies used by community-dwelling older persons. J Gerontol A Biol Sci Med Sci. 2005; 60: 1569-1575.

Williams R, Bosnic N, Duncan AW, et al.: Prevalence of opioid dispensings and concurrent gastrointestinal medications in an elderly population from Ontario, Canada. J Opioid Manag. 2008; 4: 193-200.

Simoni-Wastila L, Yang HK: Psychoactive drug use in older adults. Am J Geriatr Pharmacother. 2006; 4: 380-392.

Blixen CE, Kippes C: Depression, social support, and quality of life in older adults with osteoarthritis. Image J Nurs Sch. 1999; 31: 221-226.

Dickens C: Depression in rheumatoid arthritis: A systematic review of the literature with meta-analysis. Psychosom Med. 2002; 64: 52-60.

Weaver GD, Kuo Y-F, Raji MA, et al.: Pain and disability in older Mexican-American adults. J Am Geriatr Soc. 2009; 57: 992-999.

Edlund MJ, Steffick D, Hudson T, et al.: Risk factors for clinically recognized opioid abuse and dependence among veterans using opioids for chronic non-cancer pain. Pain. 2007; 129: 355-362.

Khantzian E: The self-medication hypothesis revisited: The dually diagnosed patient. Prim Psychiatry. 2003; 10: 231-244.

Weaver M, Schnoll S: Addiction issues in prescribing opioids for chronic nonmalignant pain. J Addict Med. 2007; 1: 2-10.

Andersen EM, Malmgren JA, Carter WB, et al.: Screening for depression in well older adults: Evaluation of a short form of the CES-D. Am J Prev Med. 1994; 10(2): 77-84.

Cleeland CS: Pain assessment in cancer. In Osoba D (ed): Effect of Cancer on Quality of Life. Boca Raton, FL: CRC Press, 1991: 293-305.

Williams VS, Smith MY, Fehnel SE: The validity and utility of the BPI interference measures for evaluating the impact of osteoarthritic pain. J Pain Symptom Manage. 2006; 31(1): 48-57.

Fillenbaum GG: Multidimensional Functional Assessment of Older Adults: The Duke Older Americans Resources and Services Procedures. Hillsdale, NJ: Erlbaum, 1988.

McCusker S, Bellavance F, Cardin S, et al.: Validity of an activities of daily living questionnaire among older patients in the emergency department. J Clin Epidemiol. 1999; 52: 1023-1030.

Thomas VS, Rockwood K, McDowell I: Multidimensionality in instrumental and basic activities of daily living. J Clin Epidemiol. 1998; 51: 315-321.

Ellison CW: Spiritual well-being: Conceptualization and measurement. J Psychol Theol. 1983; 11: 330-340.

Mitchell PH, Powell L, Blumenthal J, et al.: A short social support measure for patients recovering from myocardial infraction: The ENRICHD Social Support Inventory. J Cardiopulm Rehab. 2003; 23: 398-403.

Hermos JA, Young MM, Gagnon DR, et al.: Characterizations of long-term oxycodone/acetaminophen prescriptions in veteran patients. Arch Intern Med. 2004; 164: 2361-2366.

Ives TJ, Chelminski PR, Hammett-Stabler CA, et al.: Predictors of opioid misuse in patients with chronic pain: A prospective cohort study. BMC Health Serv Res. 2006; 6: 1-10.

Morasco BJ, Dobscha SK: Prescription medication misuse and substance use disorder in VA primary care patients with chronic pain. Gen Hosp Psychiatry. 2008; 30: 93-99.

Simoni-Wastila L, Ritter G, Strickler G: Gender and other factors associate with the nonmedical use of abusable prescription drug. Subst Use Misuse. 2004: 39(1): 1-23.

Simoni-Wastila L, Strickler G: Risk factors associated with problem use of prescription drugs. Am J Public Health. 2004; 94: 266-268.

Cohen J, Cohen P, West S, et al.: Applied Multiple Regression/Correlation Analysis for the Behavioral Sciences. 3rd ed. Mahwah, NJ: Erlbaum, 2003.

Reid MC, Williams CS, Concato J, et al.: Depressive symptoms as a risk factor for disabling back pain in communitydwelling older persons. J Am Geriatr Soc. 2003; 51: 1710-1717.

Katon W, Sullivan M, Walker E: Medical symptoms without identified pathology. Ann Intern Med. 2001; 134: 917-925.

Geerlings SW, Twisk JWR, Beekman ATF, et al.: Longitudinal relationship between pain and depression in older adults: Sex, age, and physical disability. Soc Psychiatry Psychiatr Epidemiol. 2002; 37: 23-30.

Buckner JC, Mandell W: Risk factors for depressive symptomatology in a drug using population. Am J Public Health. 1990; 80: 580-585.

Craig TJ, Van Natta PA: Current medication use and symptoms of depression in a general population. Am J Psychiatry. 1978; 135: 1036-1039.

Djernes JK: Prevalence and predictors of depression in populations of elderly: A review. Acta Psychiatr Scand. 2006; 113: 372-387.

Brucker DL: Prescription drug abuse among persons with disabilities. J Vocat Rehabil. 2008; 29: 105-115.

Dean JC, Fox AM, Jensen W: Drug and alcohol use by disabled and nondisabled persons: A comparative study. Int J Addict. 1985; 20: 629-641.

Iliffe S, Kharicha K, Carmaciu C, et al.: The relationship between pain intensity and severity and depression in older people: Exploratory study. BMC Fam Pract. 2009; 10: 54-60.

Maio V, Yuen EJ, Novielli K, et al.: Potentially inappropriate medication prescribing for elderly outpatients in Emilia Romagna, Italy. Drug Aging. 2006; 23: 915-924.

Moore D, Polsgrove L: Disabilities, developmental handicaps, and substance misuse: A review. Int J Addict. 1991; 26(1): 65-90.

Østbye T, Kristjansson B, Hill G, et al.: Prevalence and predictors of depression in elderly Canadians: The Canadian Study of Health and Aging. Chronic Dis Canada. 2005; 26(4): 93-98.

Vaccarino V, Kasl SV, Abramson J, et al.: Depressive symptoms and risk of functional decline and death in patients with heart failure. J Am Coll Cardiol. 2001; 38(1): 199-205.

Koenig HK, George LK, Titus P: Religion, spirituality, and health in medically ill hospitalized older patients. J Am Geriatr Soc. 2004; 52: 554-562.

Baetz M, Bowen R: Chronic pain and fatigue: Associations with religion and spirituality. Pain Res Manag. 2008; 13: 383-388.

Bussing A, Michalsen A, Balzat H-J, et al.: Are spirituality and religiosity resources for patients with chronic pain conditions? Pain Med. 2009; 10: 327-339.

Krause N: Social support, stress, and well-being among older adults. J Gerontol. 1986; 41: 512-518.

Potts MK: Social support and depression among older adults living alone: The importance of friends within and outside of a retirement community. Soc Work. 1997; 42: 348-362.

Isaac V, Stewart R, Artero S, et al.: Social activity and improvement in depressive symptoms in older people: A prospective community cohort study. Am J Geriatr Psychiatry. 2009; 17: 688-696.

Jones ED: Reminiscence therapy for older women with depression: Effects of nursing intervention classification in assisted-living long-term care. J Gerontol Nurs. 2003; 29(7): 26-33.

Rogers A: Factors associated with depression and low life satisfaction in the low income, frail elderly. J Gerontol Soc Work. 1999; 31(1): 167-194.

Whooley MA, Kip KE, Cauley JA, et al.: Depression, falls, and risk of fracture in older women. Arch Intern Med. 1999; 159: 484-490.

Dean A, Kolody B, Wood P, et al.: The influence of living alone on depression in elderly persons. J Aging Health. 1992; 4(1): 3-18.

Mui AC: Living alone and depression among older Chinese immigrants. J Gerontol Soc Work. 1999; 30(3/4): 147-166.

Beekman ATE, Deeg DJH, Van Limbeek J, et al.: Criterion validity of the Center for Epidemiologic Studies Depression Scale (CES-D): Results from a community-based sample of older subjects in The Netherlands. Psychol Med. 1997; 27: 231-235.

Brody BL, Gamst AC, Willams RA, et al.: Depression, visual acuity, comorbidity, and disability associated with age-related macular degeneration. Ophthalmology. 2001; 108: 1893-1900.

Cubo E, Bernard B, Leurgans S, et al.: Cognitive and motor function in patients with Parkinson’s disease with and without depression. Clin Neuropharmacol. 2000; 23: 331-334.

Braden JB, Sullivan MD, Ray GT, et al.: Trends in long-term opioid therapy for non-cancer pain among persons with a history of depression. Gen Hosp Psychiatr. 2009; 31: 564-570.

Kirsch KL, Jass C, Bennett DS, et al.: Initial development of a survey tool to detect issues of chemical coping in chronic pain patients. Palliat Supp Care. 2007; 5: 219-226.

Sullivan MD, Edlund MJ, Zhang L, et al.: Association between mental health disorders, problem drug use, and regular prescription opioid use. Arch Intern Med. 2006; 166: 2087-2093.

Published

01/15/2018

How to Cite

Lavin, MD, R., and J. Park, PhD. “Depressive Symptoms in Community-Dwelling Older Adults Receiving Opioid Therapy for Chronic Pain”. Journal of Opioid Management, vol. 7, no. 4, Jan. 2018, pp. 309-1, doi:10.5055/jom.2011.0072.

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Section

Articles